Techstars ’26 portfolio company

Use proteoforms as biomarkers, not peptides.

Any specimen, any target, any disease. Top-down proteoform analysis and support for your research project, database, or AI stack — so you can solve biology’s hardest problems. All through the power of single-particle mass spectrometry.

Overlapping proteoform spectral peaks

Backed by the people who build companies

ImmPro is a Techstars 2026 portfolio company and a participant in the Illinois Innovation Voucher program, run by the Illinois Science & Technology Coalition.

Techstars 2026Cohort Illinois Innovation Vouchers
450+
Publications from our co-founder’s lab in top-down proteomics
466 kDa
Protein complexes resolved isotopically by individual ion MS
7
Modification classes routinely localised on a single proteoform
2026
Techstars cohort — accelerating commercial deployment
The missing metric

“Proteoform” is protein identity plus site-specific modifications — which DNA can’t predict.

One protein can have dozens of proteoforms, which makes peptide proteomics a guessing game. Digest the molecule and you lose the very thing you were trying to measure: which modifications co-occur, and where.

  • Truncation
  • Phosphorylation
  • Glycosylation
  • Ubiquitination
  • Methylation
  • Acetylation
  • Lipidation
One protein diverging into multiple proteoforms carrying different modifications
What we do

Top-down analysis, delivered as a project — not a black box.

We run intact proteoform measurements on your specimens, then hand back data your team can actually build on: localised modifications, quantified proteoform ratios, and a schema that survives contact with your database.

01

Discovery & targeted biomarkers

Find the proteoform that actually separates your cohorts — in plasma, tissue, CSF or lysate — then lock it down as a targeted readout you can run again.

02

Biologics & modality characterisation

AAVs, ADCs, recombinant spike proteins and megadalton biotherapeutics: prove you are expressing the right thing, with drug-to-antibody and glycan heterogeneity measured on the intact molecule.

03

Proteoform data & AI stacks

Aggregate project data into a scalable proteoform database and fix the garbage-in/garbage-out problem at the source, before it reaches your model.

Sound familiar?

Problems we solve with proteoforms

Scientific resources

Start where your molecule is

See how single-particle, top-down protein mass spectrometry has been applied in the literature.

Leadership

Built by the lab that invented the field

Neil Kelleher, PhD

Neil Kelleher, PhD

Board Member & Co-Founder

Professor and centre director at Northwestern, with 450+ publications and pioneering work in top-down proteomics.

Jack McGee, PhD

Jack McGee, PhD

Chief Executive Officer & Co-Founder

PhD in Chemical & Biological Engineering; previously led automation at Northwestern’s Proteomics Center of Excellence.

Choon Aun Quek

Choon Aun Quek

Board Member & Co-Founder

Former Google leader with 20+ years across cloud, AI/ML and enterprise technology, including AI for genomics.

Don’t know where to start?

Let’s figure it out together. Tell us the specimen and the question — we’ll tell you whether proteoforms can answer it.